Two industrial villages developed to supplement the agricultural economy, with such businesses as the Rumford Chemical Works, but what had been the industrial area of the town in the late 18th and early 19th century was lost when East Providence was incorporated in 1862 taking half of the town's territory, two-thirds of its valuation and more than two-thirds of its population.

The town remained basically agricultural into the 20th century, although the Kent Manufacturing Company did make tennis racquets and croquet sets on the upper reaches of the Tenmile River. With the opening of the Providence and Taunton street railway in 1891, Seekonk became increasingly a residential suburb of Providence.

Seekonk Massachusetts is located in Southeastern Massachusetts, bordered by Pawtucket, Rhode Island, on the northwest; East Providence, Rhode Island, on the southwest; Attleboro on the north; Rehoboth on the east; and Swansea on the south. Seekonk is 37 miles south of Boston; 40 miles southeast of Worcester; 4 miles east of Providence.